Jose Chameleone’s career began in 1996 as a DJ at the Missouri night club in Kampala .He was later signed to the Kenyan record label Ogopa DJs. where he enjoyed his break through with one of his first singles, “Bageya”, which featured Kenyan artist Redsan.
Chameleone’s musical style is a combination of Ugandan folk music, central African rumba, zouk and reggae. His first album, Bageya, was released in 2000. By 2013, he had released twelve more albums, including Mama Mia in 2001, Njo Karibu and The Golden Voice in 2003, Mambo Bado in 2004, Kipepeo in 2005, Shida za Dunia in 2006, Sivyo Ndivyo and Katupakase in 2007, Bayuda in 2009, Vumilia in 2010, Valu Valu in 2012, Badilisha in 2013 and Tubonge in 2014.
He is president of Ugandan music label Leone Island. Leone Island has signed many musicians from Uganda and East Africa, including Moses Radio, Weasel, AK 47, King Saha, Papa Cidy, Pallaso and many more.
In March 2014 at the Lugogo Cricket Oval Stadium in Kampala, Chameleone broke the record for the largest audience of any East African performer, drawing an estimated 40,000 fans to his “Tubonge Live” concert. The speaker of the parliament of Uganda, Rebecca Kadaga, designated Chameleone to be the Ambassador of the Busoga Tourism Initiative.